Computational approaches to understand cardiac electrophysiology and arrhythmias

Computational approaches to understand cardiac electrophysiology and arrhythmias.

Cardiac rhythms arise from electrical activity generated by precisely timed opening and closing of ion channels in individual cardiac myocytes. These impulses spread throughout the cardiac muscle to manifest as electrical waves in the whole heart. Regularity of electrical waves is critically important since they signal the heart muscle to contract, driving the primary function of the heart to a...

Computers and arrhythmias: computational approaches to understanding cardiac electrical dynamics

Heart disease is one of the most prevalent diseases in the world and is the leading cause of death in industrialized countries. In the United States alone, cardiovascular disease affects about 68 million people, roughly 25% of the total population, from both sexes, and all races and ages, and costs an estimated $117 billion annually. It is currently believed that most dangerous cardiac arrhythm...

Introduction to Cardiac Electrophysiology, the Electrocardiogram, and Cardiac Arrhythmias

Overall cardiac output (the amount of blood the heart pumps around the body every minute) is a function of how much blood the heart ejects with every beat, and the heart rate. Many factors work in concert to regulate heart rate. A thorough understanding of normal mechanisms of cardiac electrical activation and modifying factors is a necessary precursor to understanding disease states, and their...

Protective effects of gallic acid on cardiac electrophysiology and arrhythmias during reperfusion in diabetes

Objective(s): Gallic acid (GA), a potent anti-oxidant, plays an important role in reducing diabetic induced cardiac disorders. Therefore, the present investigation was purposed to determine the beneficial effect of GA in cardiac arrhythmias during reperfusion in diabetes induced by alloxan. Materials and Methods: Male Sprague-Dawley rats...

Introduction to the series on Computational Approaches to Cardiac Arrhythmias: Translation Into Diagnostics and Therapy.